Synthetic Route of 60811-21-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60811-21-4 name is 4-Bromo-2-chloro-1-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a 250 mL three-necked flask was added magnesium turnings (3.60 g, 150 mmol) and anhydrous THF (150 mL) under argon. A few drops of 1,2-dibromoethane were added followed by the slow addition of 1-bromo-4-fluorobenzene (13.1 g, 75.0 mmol). The solution was stirred at ambient temperature for 40 min, then cooled to 0 C, at which time the solution was added slowly to 2-(tert-butyldimethylsilyloxy)-N-methoxy-N-methylacetamide 6 (10.0 g, 42.8 mmol) in THF (150 mL). The resultant mixture was stirred at 0 C for 3 h, then quenched with saturated NH4Cl (100 mL). The mixture was extracted with CH2Cl2 (3 ¡Á 100 mL) and the combined organic phases washed with water (3 ¡Á 100 mL), dried (Na2SO4), and concentrated. The residue was purified by column chromatography (1:20 EtOAc/petroleum ether) to afford 10 g (91%) of 2-(tert-butyldimethylsilyloxy)-1-(4-fluorophenyl)ethanone as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chloro-1-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Article; Pan, Xingang; Jia, Liangbin; Liu, Xuejian; Ma, Haikuo; Yang, Wenqian; Schwarz, Jacob B.; Tetrahedron Asymmetry; vol. 22; 3; (2011); p. 329 – 337;,
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