Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1513-25-3, name is 2-Chloro-1-fluoro-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6ClF
Potassium ethoxide (1.74 g, 20.7 mmol) was dissolved in anhydrous diethyl ether (50 mL), was added dropwise diethyl oxalate (1g, 6.9mmol) in anhydrous diethyl ether (20mL) at room temperature, then added dropwise chloro-1-fluoro-4-methyl-benzene (1g, 6.9mmol) in anhydrous diethyl ether (20mL) at rt was stirred room temperature for 30 hours. Quenched with ice water, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product purified by column chromatography, to give ethyl 3-(3-chloro-4-fluorophenyl)-2-carbonylpropionate (610mg, yield 36%)
According to the analysis of related databases, 1513-25-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Liu Shiqiang; Zhou Yuanfeng; Bao Meng; Yuan Yida; Liu Lei; Bao Rudi; (57 pag.)CN109761986; (2019); A;,
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