Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Recommanded Product: 309721-44-6
40.0 g (1.0 eq) of Compound 1 (5,12-dihydroindolo [3,2-a] carbazole) and 26.27 g (1.5 eq) of Potassium tert-butoxide (KOtBu) were dissolved in dimethylformamide (DMF)And the mixture was heated and stirred.At the start of the reflux, 40.0 g (1.1 eq) of compound 1a (2-bromo-1-chloro-3-fluorobenzene) was added.After the reaction was completed after 3 hours, the reaction was poured into water and the crystals were dropped and filtered.The filtered solid was completely dissolved in chloroform (CHCl3), washed with water, and again reduced in pressure to remove the solvent. The residue was purified by column chromatography to obtain 49.5 g of Compound A-1 (yield: 71%).
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Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; (125 pag.)KR2017/126814; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics