Adding a certain compound to certain chemical reactions, such as: 7149-75-9, name is 4-Chloro-3-methylaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7149-75-9, Product Details of 7149-75-9
tert-butyl 4-oxopiperidine-l-carboxylate (1 g, 5.02 mmol) and 4-chloro-3- methylaniline (711 mg, 5.02 mmol), were dissolved in DCE (30 mL) and acetic acid (287 mul, 5.02 mmol) was added. The reaction was stirred at 60 ¡ãC for 6 h. The reaction was allowed to cool and Sodium Tri(acetoxy)borohydride (1.49 g, 7.03 mmol) was added. The reaction was then stirred at room temperature for 18 h, then washed with water and brine. The organic layer was dried and concentrated, then purified using column chromatography (Biotage, 25g SNAP KP-SIL, 100percent DCM, 10CV). The crude product was then purified a second time using low pH reverse phase column chromatography to yield a white solid (130 mg, 8percent). LCMS Method D: rt 1.64 min, 92 percent; m/z. 269.1 (MH+-*Bu)
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Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; EVOTEC INTERNATIONAL GMBH; GAMPE, Christian, M.; KAHNE, Daniel, Evan; KAHNE, Suzanne, Walker; QIAO, Yuan; EAST, Stephen; PARKES, Alastair, L.; SOUTHEY, Michelle; HUNTER, James; WHITTAKER, Mark; ARTHUIS, Martin; (359 pag.)WO2016/191658; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics