Reference of 7149-75-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7149-75-9, name is 4-Chloro-3-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A solution of the corresponding aniline (0.5 mmol) in dry THF(4 mL/mmol) was treated with Et3N (5.4 mmol) under inert atmosphere.After stirring the mixture for 5 min, the carbamate derivedfrom AmCA-4 (prepared following the described procedure [20])(0.5 mmol) was added dissolved in THF (10 mL/mmol). The resultingmixture was then stirred in the dark at 40-50 C for 24-72 h(TLC monitoring). After this time, CH2Cl2 (15 mL) and HCl 1M were added to the reaction mixture, which was then extracted withCH2Cl2 (2 x 10 mL). The organic layer was washed with brine, and then dried on anhydrous Na2SO4. Removal of volatiles under reduced pressure afforded an oily residue which was subjected to column chromatography on silica-gel (Hexane-EtOAc mixtures as eluent) to afford the desired products with the yields indicated below.
The synthetic route of 4-Chloro-3-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Conesa-Milian, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 781 – 792;,
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