Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1871-57-4
To a solution of 3-chloro-2-chloromethyl-1-propene (methallyl dichloride, 3.00 g, 24.0 mmol)and propargyl alcohol (8.50 mL, 144 mmol) in an ice bath was added sodium hydride (50%in mineral oil, 7.60 g, 158 mmol) portionwise over 1 h. After removing the ice bath, thereaction solution was stirred for another 1 h and then methanol was added. The resultingsolution was concentrated under reduced pressure. The residue was diluted with ethylacetate, washed with an ice-cooled water and a saturated NaCl solution, dried over MgSO 4 ,filtered, and concentrated under reduced pressure. The resulting material was purified bycolumn chromatography on silica gel (50 mL of the gel bed volume, hexane:ethyl acetate =20:1) to give 6 as colorless transparent oil (3.19 g, 81%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1871-57-4.
Reference:
Article; Matsushita, Takahiko; Tsuchibuchi, Koji; Koyama, Tetsuo; Hatano, Ken; Matsuoka, Koji; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1704 – 1707;,
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