In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21711-56-8 as follows. Product Details of 21711-56-8
Under a nitrogen stream, a-1 (20.0 g, 66.85 mmol) synthesized in Preparation Example 1, A-2 (17.40 g, 66.85 mmol) synthesized in Preparation Example 2,Pd (OAc) 2 (1.50 g, 6.69 mmol),NaOtBu (16.06 g, 167.12 mmol) and P (t-Bu) 3 (2.70 g, 13.37 mmol) were placed in 400 ml of xylene and stirred at 150 degree For 24 hours. After completion of the reaction, the mixture was extracted with methylene chloride, concentrated under reduced pressure, and 30.9 g of b-1 was obtained by column chromatography.
According to the analysis of related databases, 21711-56-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DOOSAN CORPORATION; Jo, Hung Sang; KIM, Chung Han; PARK, Ho Chul; LEE, CHANG JUN; SIN, JIN YONG; LEE, JAE HUN; Baek, Young Mi; (18 pag.)KR2015/103949; (2015); A;,
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