Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1303587-99-6
Synthesis of 8-benzyl-2-chloro-7 , 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0457] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (3.5 mL) under argon atmosphere were added sodium hydride (28 mg, 1.16 mmol) and bromomethylbenzene (216 mg, 1.16 mmol) at 0 C. The reaction mixture was warmed to RT and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 40% EtOAc:hexane to afford 8-benzyl-2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (120 mg, 75%) as an off-white solid. 1H-NMR (DMSO-<, 500 MHz): delta 7.62 (s, 1H), 7.30-7.20 (m, 5H), 4.10-4.08 (m, 2H), 3.78 (t, 2H), 3.49-3.47 (m, 2H), 2.88 (t, 2H); LCMS: 275.8 (M+); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 mupiiota); RT 3.64 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.6).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1303587-99-6.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
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