Synthetic Route of 39226-95-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39226-95-4 as follows.
Compound 8 (50 mg, 0.123 mmol) was dissolved in methanol (3 mL), and under the protection of nitrogen, 2,3-dichlorobenzylamine (24 mg, 0.135 mmol) was sequentially added.DMTMM (37.4 mg, 0.135 mmol), N-methylmorpholine (30 muL), reacted at room temperature overnight, TLC detection of starting materials disappeared (developing solvent: dichloromethane-methanol = 10: 1).The solvent was distilled off under reduced pressure, diluted with ethyl acetate, washed successively with water, saturated brine, dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated under reduced pressure. The obtained crude product was separated by silica gel column chromatography (mobile phase: dichloromethane-methanol = 20: 1) Purification gave 9m (50 mg, 71%) of a white solid compound.
According to the analysis of related databases, 39226-95-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Academy Of Medical Sciences Pharmaceutical Institute (Shandong Kang Shuailao Research Center ? Shandong Xin Technology Pharmaceutical Institute); Yao Qingqiang; Liu Bo; Yu Kun; Yang Xinmei; Song Linlin; Li Ying; Chen Haijiao; (29 pag.)CN110818759; (2020); A;,
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