According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.
Electric Literature of 69957-83-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 69957-83-1 as follows.
To a solution of N-(4-chlorobenzyl)-JV-ethylamine (0.150 g, 0.88 mmol) and {4-[(25)-2,3- diethoxy-3-oxopropyl]phenoxy}acetic acid (0.270 g, 0.91 mmol) in methylene chloride (10 mL) were added iVyV-diisopropylethylamine (0.34 mL, 1.9 mmol) and O-(benzotriazol-l-yl)- EPO tetrafluoroborate (0.320 g, 1.00 mmol) and the reaction mixture was stirred at room temperature overnight. The resulting solution was diluted with methylene chloride (40 mL) and the organic phase was washed with 5% HCl (50 mL), saturated aqueous NaHCO3 (50 mL), and brine (50 mL), dried over Na2SO4, and concentrated in vacuo. 5 Purification on a prepacked column of silica gel (Isolute SPE Column, 50 g/150 mL) with methylene chloride/ethyl acetate 10:1 as the eluent yielded 0.24 g (61%) of a colourless oil.1H NMR (500 MHz, CDCl3): delta 1.05-1.24 (m, 9H), 2.88-3.00 (m, 2H), 3.28-3.42 (m, 3H), 3.60 (m, IH), 3.96 (m, IH)3 4.12-4.20 (m, 2H), 4.56 and 4.58 (2s, 2H, rotamers), 4.64 and 4.73 (2s, 10 2H, rotamers), 6.75 and 6.88 (2d, 2H, rotamers), 7.09-7.20 (m, 4H), 7.24 and 7.30 (2d, 2H, rotamers).
According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2007/8156; (2007); A1;,
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