These common heterocyclic compound, 78068-85-6, name is 3-Chloro-4-fluorobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H3ClF4
To a suspension of 3,3′-dihydroxydiphenyl disulfide (1.01 g, 4.03 mmol) and Cs2CO3 (3.3 g, 10 mmol) in DMF (20 mL) was added 3-chloro-4-fluorobenzotrifluoride (2 g, 10 mmol). The reaction was heated at 100 C. overnight. The mixture was then cooled and partitioned between ether (200 mL) and water (200 mL). The aqueous layer was further extracted with ether (2¡Á100 mL). The organic layers were combined, washed with water (1¡Á100 mL), Brine (1¡Á100 mL), dried with anhydrous sodium sulfate, filtered and concentrated. The resulting oil was used in the next step directly.
The synthetic route of 3-Chloro-4-fluorobenzotrifluoride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ge, Min; He, Jiafang; Lau, Fiona Wai Yu; Liang, Gui-Bai; Lin, Songnian; Liu, Weiguo; Walsh, Shawn P.; Yang, Lihu; US2007/265332; (2007); A1;,
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