928782-97-2, name is 4-Chloro-2-(phenylethynyl)aniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C14H10ClN
General procedure: The substituted 2-alkynylaniline (1.0 mmol) was dissolved in acetonitrile (5.0 mL) and stirred until the solution became homogeneous. To this solution, methyl vinyl ketone (1.5 mmol) followed by 20 mol % of PdCl2 (59-60%, 35 mg) was added under a nitrogen atmosphere, then heated to 60 C and monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature and the acetonitrile was removed by vacuum evaporation. The resulting crude product was purified by column chromatography to afford the desired 2,3-disubstituted indoles. 4-(5-Chloro-2-phenyl-1H-indol-3-yl)pentan-2-one (3q) Yield: (218 mg, 70%); Colorless solid. Mp: 170-171 C. FT-IR (KBr) (nu/cm-1): 3423, 1638. 1H NMR (400 MHz, CDCl3) deltaH (ppm): 8.08 (br s, 1H), 7.70 (d, J=1.9 Hz, 1H), 7.52-7.44 (m, 4H), 7.42-7.37 (m, 1H), 7.27-7.24 (m, 1H), 7.15-7.12 (m, 1H), 3.79-3.70 (m, 2H), 3.01-2.88 (m, 2H), 1.98 (s, 3H), 1.44 (d, J=7.0 Hz, 3H). 13C NMR (100 MHz, CDCl3) deltaC (ppm): 208.3, 135.9, 134.7, 132.8, 129.0, 128.9, 128.4, 128.3, 125.1, 122.3, 119.7, 116.3, 112.3, 50.5, 30.6, 27.0, 21.5. LRMS (EI) (m/z) (relative intensity): 311 (M+, 38), 254 (100); HRMS calcd for C19H18Cl1O1N1 (M+): 311.1077, found 311.1080.
The synthetic route of 928782-97-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Janreddy, Donala; Kavala, Veerababurao; Kuo, Chun-Wei; Kuo, Ting-Shen; He, Chiu-Hui; Yao, Ching-Fa; Tetrahedron; vol. 69; 15; (2013); p. 3323 – 3330;,
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