Reference of 19752-55-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19752-55-7 as follows.
To a stirred solution of [2-(4-aminophenyl)-acetylamino]-acetic acid terf-butyl ester (0.200 g, 0.76 mmol), 3,5-dichloro-1-bromobenzene (0.186 g, 0.83 mmol), K2CO3 (0.524 g, 3.80 mmol) and xantphos (0.050 g, 0.087 mmol) in 1 ,4-dioxane (2ml) under nitrogen in a microwave tube was added Pd2dba3 (0.050 g, 0.054 mmol) in one portion and the tube sealed. The reaction was heated with stirring in a microwave at 1600C for 75 minutes. The reaction was cooled before filtering through celite and concentrating in vacuo. The reaction mixture was purified by preparative column chromatography using acidic eluent. The purified tert-butyl ester product was dissolved in 3:1 DCM:trifluoroacetic acid (4 ml) and the reaction stirred at room temperature overnight. The reaction was concentrated in vacuo and the crude product purified by preparative chromatography to afford the named product (10.6 mg). LCMS R,=3.76 min, m/z (ES+) 353 (M+H).
According to the analysis of related databases, 19752-55-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LECTUS THERAPEUTICS LIMITED; EDWARDS, Simon David; KIMBERLY, Meriel Ruth; ARMER, Richard Edward; KHAN, Nawaz Mohammed; WO2010/10380; (2010); A1;,
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