Electric Literature of 16799-05-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16799-05-6, name is 3-Chlorophenethyl Bromide, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: TBAB (0.443g, 1.38mmol), phenethyl bromide (0.65mL, 2.50mmol) and 5.0mL of 25% m/m NaOH solution were added to a solution of 10a (0.25g, 1.275mmol) in 15mL of dry DCM. The mixture was stirred at rt for 48h, and then diluted with 20mL of DCM and 20mL of water. The collected organic phase was washed twice with 20mL of brine, dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluting with ethyl acetate, to afford 12b as pale brown solid (0.270g, 70% yield).
The chemical industry reduces the impact on the environment during synthesis 3-Chlorophenethyl Bromide. I believe this compound will play a more active role in future production and life.
Reference:
Article; de Candia, Modesto; Zaetta, Giorgia; Denora, Nunzio; Tricarico, Domenico; Majellaro, Maria; Cellamare, Saverio; Altomare, Cosimo D.; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 288 – 298;,
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