In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16793-91-2 as follows. Product Details of 16793-91-2
Example 8A Di-tert-butyl (2-{5-[2-(2-chlorophenyl)ethoxy]-1-benzofur-2-yl}-2-oxoethyl)[2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]malonate To a mixture of 100 mg (0.18 mmol) of the compound from Example 7A in 2.5 ml of acetonitrile were added 47 mg (0.21 mmol) of 1-(2-bromoethyl)-2-chlorobenzene and 49 mg (0.36 mmol) of potassium carbonate and the mixture was stirred under reflux for 1.5 h. Then, a further 47 mg (0.21 mmol) of 1-(2-bromoethyl)-2-chlorobenzene and 49 mg (0.36 mmol) of potassium carbonate were added and the mixture was stirred under reflux for a further 4.5 h. Then, the mixture was left to stand firstly overnight at RT and then, after another addition of 47 mg (0.21 mmol) of 1-(2-bromoethyl)-2-chlorobenzene, stirred for a further 5 h at 50 C. After cooling to RT, the mixture was admixed with 1 ml of water and purified directly by preparative HPLC (Method 7). The combined product-containing fractions were neutralized with saturated aqueous sodium hydrogencarbonate solution, concentrated to a residual volume of aqueous phase and extracted twice with dichloromethane. The combined organic phases were dried over magnesium sulphate and concentrated, and the residue was dried in vacuo. 21 mg (17% of theory, purity 100%) of the title compound were obtained. LC/MS (Method 1, ESIpos): Rt=1.59 min, m/z=702 [M+H]+.
According to the analysis of related databases, 16793-91-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BECK, Hartmut; LI, Volkhart Min-Jian; CANCHO GRANDE, Yolanda; TIMMERMAN, Andreas; BROHM, Dirk; JOeRIssEN, Hannah; BOGNER, Pamela; GERISCH, Michael; LANG, Dieter; (120 pag.)US2017/121315; (2017); A1;,
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