In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7006-52-2 as follows. Computed Properties of C7H8ClN
To a solution of 4-chloro-l-methyl-lH-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester (0.5g) in 1,4-dioxane (5ml) was added 3-chloro-N-methyl aniline (0.629g) and methanesulfonic acid (0.289ml). The mixture was irradiated under microwave conditions at 180¡ãC for 30min. 1,4-dioxane was removed in vacuo and the residue purified by MDAP to give the title compound (350mg). LC/MS [MH+] 330 consistent with molecular formula C17H1635ClN3O2
According to the analysis of related databases, 7006-52-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/121140; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics