Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 367-22-6, name is 4-Chloro-3-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 367-22-6
Step 14: Preparation for N-(4-Chloro-3-fluorophenyl)-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]-quinazolin-10-amine To a solution of 10-Chloro-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline (0.1 g, 0.3 mmol) in isopropanol (3 mL) was added 4-chloro-3-fluoroaniline (0.06 g, 0.4 mmol). The solution was stirred at 80 C. for 4 hours. After cooling to ambient temperature, the solution was concentrated to obtain a yellow solid which was purified by column chromatography on silicon gel (dichloromethane:methanol=100:1) to obtain a yellow solid (0.07 g, yield=49%). 1H NMR (DMSO-d6, 400 MHz): 10.51 (s, 1H), 8.75 (s, 1H), 7.95-7.92 (m, 1H), 7.65-7.64 (m, 1H), 7.54 (t, 1H, J=8.9 Hz), 7.30 (s, 1H), 4.77 (dd, 1H, J=4.4 Hz), 4.61 (br, 2H), 4.60 (br, 2H), 3.92-3.89 (m, 2H), 3.56-3.50 (m, 2H), 2.10-2.07 (m, 2H), 1.72-1.69 (m, 2H); MS: 432(M+H+).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 367-22-6.
Reference:
Patent; BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED; SHENG, Wang; YANG, Leifu; PAN, Zhiyong; (46 pag.)US2017/355683; (2017); A1;,
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