Application of 1871-57-4, These common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Compound 1 (1.32 g, 10.5 mmol) in DMF (20 mL) was added NaH (960 mg, 24 mmol) at 0 C., the mixture was stirred at 0 C. for 30 min. Then compound 2 (1.61 g, 10 mmol) was added at 0 C. The mixture was stirred at 15 C. for 2 hours. TLC showed that starting material was consumed completely. Saturated NH4Cl (100 mL) was added to quench the reaction. The solvent was removed in vacuo and the residue was extracted with EA (100 mL*2). The organic layer was concentrated and purified by silica gel column (PE:EA=4:1) to give compound 3 (1.1 g, yield: 51%) as colorless oil. 1H NMR (400 MHz, CDCl3): delta: 5.12-4.91 (m, 2H), 4.29-4.03 (m, 4H), 3.76-3.45 (m, 4H), 1.47 (s, 9H).
Statistics shows that 3-Chloro-2-chloromethyl-1-propene is playing an increasingly important role. we look forward to future research findings about 1871-57-4.
Reference:
Patent; Novira Therapeutics, Inc.; Hartman, George D.; US2015/225355; (2015); A1;,
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