Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7464-11-1, name is 5,7-Dichloro-2-methylthiazolo[5,4-d]pyrimidine, A new synthetic method of this compound is introduced below., Computed Properties of C6H3Cl2N3S
To interemdiate 17.6 (123 mg, 0.62 mmol, 1.03 equiv) and compound 23.1 (132 mg, 0.60 mmol, 1.00 equiv) in 2-butanol (5 mL) was added DIEA (155 mg, 1.20 mmol, 2.00 equiv) and the resulting solution was stirred for 4 h at 100 C under nitrogen. The resulting mixture was concentrated under vacuum and crude was purified using flash column chromatography to furnish 160 mg of intermediate 29.1 as a white solid. LCMS (ES, m/z): 382 and 384 [M+H].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
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