Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, Recommanded Product: 14862-52-3
The following reagents and solvent were charged into a reaction vessel. Tris(dibenzylideneacetone)dipalladium(0): 190 mg (0.21 mmol) Tri(t-butyl)phosphine: 170 mg (0.82 mmol) Toluene: 20 ml. Next, the reaction solution was stirred at room temperature for 15 minutes. After that, the following reagents were charged into the reaction solution. Compound J13: 560 mg (2.1 mmol) Compound J14: 1.0 g (4.6 mmol) t-Butoxysodium: 880 mg (9.1 mmol). Next, the reaction solution was heated to 100 C. and then stirred at the temperature (100 C.) for 3 hours. After the completion of the reaction, the reaction solution was cooled and then an organic layer was extracted with toluene. Next, the extracted organic layer was dried and then the solvent was removed by distillation under reduced pressure to provide a coarse product. Next, the coarse product was purified by silica gel column chromatography (developing solvent; heptane_toluene=3:1) to provide 760 mg (yield: 67%) of Compound J15.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromochlorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Canon Kabushiki Kaisha; Nishide, Yosuke; Yamada, Naoki; Kamatani, Jun; Ishii, Ryuji; Kajimoto, Norifumi; Ito, Takayuki; Mizuno, Nobutaka; Ishige, Koichi; Saitoh, Akihito; (71 pag.)US9755165; (2017); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics