Related Products of 329944-72-1, These common heterocyclic compound, 329944-72-1, name is 3-Bromo-5-chlorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : To a solution of 3-bromo-5~chlorotoluene (754 mg, 3,67 mmol) in diethyl ether (20 mL) was added dropwise butyllithium (1.5 mL, 3.67 mmol) at -78 C. The resulting solution was stirred at -78 C for 0.5h before addition of 3a (558 mg, 1.835 mmol) as one portion. The reaction mixture was stirred from -78 C to rt over 16h before quenching with sat. NaHCPatent; MERCK SHARP & DOHME CORP.; DING, FA-Xiang; JIANG, Jinlong; SHEN, Dong-Ming; SHEN, Hong; SHI, Zhi-Cai; WO2011/137024; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics