Synthetic Route of 1005-56-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1005-56-7, name is O-Phenyl carbonochloridothioate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of compound 14 (200 mg, 0.47 mmol) in THF (5 mL), was added nBuLi (370 muL, 0.59 mmol, 1 .6 M in hexanes) at -78 C. The resulting solution was stirred at 78 C for 30 min before a solution of O-phenyl chlorothionoformate (100 muL, 125 mg, 0.723 mmol) in THF (1 mL) was added. The resulting mixture was allowed to warm to 0 C and stirred for 3 h before it was quenched with a saturated solution of NH4CI (10 mL) and diluted with CH2CI2 (10 mL). The layers were separated, and the aqueous layer was extracted with CH2CI2 (4 x 5 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, hexanes: EtOAc 10: 1 ? 5: 1 ) to give compound 15 (243 mg, 92%; mixture of inseparable diastereoisomers) as a yellow oil. (0320) [00240] 1 H NMR (400 MHz, CDCI3) delta = 8.16 (d, J = 7.4 Hz, 1 H), 7.61 – 7.49 (m, 5H), 7.46 – 7.40 (m, 3H), 7.39 – 7.32 (m, 5H), 7.30 – 7.23 (m, 3H), 7.10 (dq J = 1 1 .0, 6.6 Hz, 1 H), 6.82 – 6.77 (m, 2H), 5.28 (s, 2H), 4.68 (d, J = 1 1 .0 Hz, 1 H), 3.12 (s, 3H); 19F NMR (376 MHz, CDCI3) delta = -78.87 (d, J = 6.6 Hz, 3F).
The synthetic route of O-Phenyl carbonochloridothioate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO; GREIG, Iain; ZANDA, Matteo; TSENG, Chih-Chung; ROSS, Ruth; (134 pag.)WO2016/29310; (2016); A1;,
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