Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine, A new synthetic method of this compound is introduced below., SDS of cas: 1303587-99-6
Synthesis of 2-chloro-8-methyl-7, 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0425] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (5 mL) under argon atmosphere were added potassium carbonate (242 mg, 1.75 mmol) and methyl iodide (0.03 mL, 0.58 mmol) at RT. The reaction mixture was stirred for 16 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (10 mL) and extracted with EtOAc (2 x 10 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was washed with n-hexane (2 x 5 mL) to afford 2-chloro-8-methyl-7, 8- dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (28 mg) as a white solid. This compound was used without further purification. 1H-NMR (CD3OD, 500 MHz): delta 7.54 (s, 1H), 4.23-4.20 (m, 2H), 3.60-3.58 (m, 2H), 3.19 (s, 3H); LCMS: 186.1 (M+1); (column; X-Select CSH C-18 (50 x 3.0 mm, 3.5 mupiiota); RT 1.76 min. 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 50% EtOAc/hexanes (Rf: 0.6).
The synthetic route of 1303587-99-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
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