Electric Literature of 13918-92-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13918-92-8 as follows.
To an ice cooled solution of 5′-amino-7′-nitrospiro[cyclobutane-1,3′-indolin]-2′- one (2.0 g, 8.58 mmol) in DCM (20 mL) were added pyridine (1.4 mL, 17.16 mmol) followed by 2,4-difluorobenzenesulfonyl chloride (1.7 mL, 12.87 mmol) dropwise. The mixture was at RT for 3 h. The mixture was diluted with DCM (100 mL), washed with water (100 mL) and brine (100 mL), dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as yellow solid (2.5 g, 89 %.).1H NMR (400 MHz, DMSO-d6): delta 11.0 (s, 1H), 10.86 (s, 1H), 7.95-7.83 (m, 1H), 7.68 (d, J=1.5 Hz, 1H), 7.62 (d, J=1.5 Hz, 1H), 7.56 (t, J=8.8 Hz, 1H), 7.30-7.25 (m, 1H), 2.47-2.40 (m, 2H), 2.35-2.12 (m, 4H).
According to the analysis of related databases, 13918-92-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORION CORPORATION; UJJINAMATADA, Ravi Kotrabasaiah; SAMAJDAR, Susanta; ABBINENI, Chandrasekhar; MUKHERJEE, Subhendu; LINNANEN, Tero; WOHLFAHRT, Gerd; (220 pag.)WO2016/203112; (2016); A1;,
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