These common heterocyclic compound, 57946-56-2, name is 4-Chloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Chloro-2-fluoroaniline
Example 3 Production of the nitroaniline (XIII):- 4-Chloro-2-fluoroaniline (23 g) was dissolved in conc, sulfuric acid (120 ml), and the resultant mixture was cooled to -20C, followed by dropwise addition of fuming nitric acid (15 g). The reaction mixture was stirred at -20 to -15C for 1.5 hours, poured into ice-water and then extracted with ether. The ether extract was washed with water and a saturated sodium bicarbonate solution, dried and concentrated. The residue was crystallized from a mixture of toluene and hexane (2: 1) to obtain 20 g of 4-chloro-2-fluoro-5-nitroaniline. M.P., 83 – 84.5C.
The synthetic route of 4-Chloro-2-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; EP208374; (1991); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics