Synthetic Route of 20850-43-5, A common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, molecular formula is C8H7ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 7:Preparation of compound Ig: 2-(Benzo[l,3]dioxol-5-ylmethyl-methyl-amino)-ethanol.2-(Methylamino)ethanol (22.0 g, 290 mmol) was added to a stirred solution of 3,4- methylenedioxybenzyl chloride (25.0 g, 147 mmol) in DCM (45 mL) at -780C under nitrogen. The solution was stirred for 15 minutes at -780C then warmed to room temperature and stirred for 16h. 1.2 M NaOH (100 mL) was added and the phases were separated. The organic layer was washed water (2 x 150 mL) and concentrated under vacuum to give 25.3 g (83%) of 2-(benzo[l,3]dioxol-5-ylmethyl- methyl-amino)-ethanol as a clear oil.
The synthetic route of 20850-43-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KALYPSYS, INC.; WO2007/62417; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics