Reference of 18655-50-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18655-50-0 as follows.
EXAMPLE 5 2-[N-(3-(p-Chlorophenyl)propylamino)]-5-hydroxy-4-methylpyrimidine [Formula I: R=H; R’=pCl-C6 H4 (CH2)3 ] A mixture of 2.5 g (0.02 mole) of 5-acetyl-2-aminooxazole, 10.5 g (0.062 mole) of 3-(p-chlorophenyl)propylamine, and 2.7 ml of water was heated at 110 C. (external) for 16 hours. The mixture was allowed to cool to room temperature and diluted with 15 ml of water. The resulting precipitate, which is 2-[N-(3-(p-chlorophenyl)propylamino)]-5-acetyl-1H-imidazole, was collected and set aside. Concentration of the filtrate afforded as oil which was chromatographed over silica gel using 1:1 ethyl acetate/hexane as eluent. The less polar material was the desired product which was isolated as a solid. Recrystallization from acetonitrile afforded 0.71 g (13%) of the title compound, mp 99-100 C.
According to the analysis of related databases, 18655-50-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc.; US4554276; (1985); A;,
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