These common heterocyclic compound, 108-41-8, name is 1-Chloro-3-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H7Cl
A mixture of 1-chloro-3-methyl benzene (126 mg, 1 mmol), thiophenol (110 mg, 1 mmol), NaOH (60 mg, 1.5 mmol) and 5 mol % NiL2 (38 mg) in DMF was stirred at 70 C for 3 h. The reaction mixture was filtered and the solvent evaporated in vacuo to give the crude product, which was purified by column chromatography (hexane/ethyl acetate=10/1) to give the title compound 3j (152 mg, 76%) as a colourless oil; [Found: C, 77.90; H, 6.12. C13H12S requires C, 77.95; H, 6.04%]; Rf=0.4 (hexane/ethyl acetate=10/1). 1H NMR (400 MHz, CDCl3): delta 7.33-7.21 (m, 9H), 2.33 (s, 3H). 13C NMR (100 MHz, CDCl3): delta 139.6, 136.2, 135.4, 131.7, 130.4, 129.4, 129.1, 128.4, 128.2, 126.7, 21.4.
The synthetic route of 1-Chloro-3-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gogoi, Prasanta; Hazarika, Sukanya; Sarma, Manas J.; Sarma, Kuladip; Barman, Pranjit; Tetrahedron; vol. 70; 41; (2014); p. 7484 – 7489;,
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