Related Products of 85462-59-5, These common heterocyclic compound, 85462-59-5, name is 2-Bromo-5-chloro-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 39; 4-Chloro-5-fluoro-2-(4-phenoxy-benzoylamino)-benzoic acid Step 1: N,N-di-tert-Butyloxycarbonyl-2-bromo-5-chloro-4-fluoro-aniline This compound was prepared in analogy to the method of Darnbrough et al. (Synth. Comm. 2001, 31, 3273): Under an atmosphere of Nitrogen, di-tert-butyl dicarbonate [24424-99-5], 8.839 g) was added to a cooled (0 C.) solution of 2-bromo-5-chloro-4-fluoro-aniline ([85462-59-5], 3.03 g) and DMAP (0.165 g) in THF (20 ml). After 4 h at r.t., the reaction mixture was taken up in ethyl acetate, washed with 1N HCl and brine, and dried (Na2SO4). The solvent was evaporated and the residue purified by column chromatography (silica gel, n-heptane, ethyl acetate) to give the title compound (4.66 g, 81%). 1H NMR (CDCl3): delta 1.42 (s, 18H), 7.28 (d, 1H), 7.42 (d, 1H).
The synthetic route of 85462-59-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Narquizian, Robert; Panousis, Constantinos; Peters, Jens-Uwe; US2006/281810; (2006); A1;,
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