These common heterocyclic compound, 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-N,N-dimethylethanamine hydrochloride
NaN3(13.7 g, 210 mmol) was added into a solution of 2-chloro-N,N- dimethylethylamine hydrochloride (10.0 g, 70 mmol) in 100 mL water and the reaction mixture was heated to 70 C for overnight. The solution was basified with 4 M NaOH solution and extracted with anhydrous diethyl ether three times. The resulting solution was dried over MgS04 and concentrated to give volatile colorless oil. (5.9 g, 74%)1H NMR (CDC13, 400 MHz): delta 3.31 (t, 2H), 2.45 (t, 2H), 2.21 (s, 6H, N(CH3)2).
The synthetic route of 2-Chloro-N,N-dimethylethanamine hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CORNELL UNIVERSITY; MA, Minglin; LIU, Qingsheng; (140 pag.)WO2018/140834; (2018); A1;,
Chloride – Wikipedia,
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