Reference of 367-22-6, These common heterocyclic compound, 367-22-6, name is 4-Chloro-3-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of substituted anilines (4.70 mmol) in toluene (25 mL) was added to the above reaction solution, followed by stirring for 3 h. Upon completion of the reaction, the resulting mixture was cooled to 20 C.The solid thus obtained was filtered under a reduced pressure and washed with toluene (20 mL). Isopropanol (18 mL) was added to thesolid, which was then stirred for 5 h. The resulting solid was filtered and washed with isopropanol (10 mL). The solid was dried at 50 C in the oven to afford 3a-f as white powder.
Statistics shows that 4-Chloro-3-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 367-22-6.
Reference:
Article; Cai, Zhi-Qiang; Jin, Zheng-Sheng; Zheng, De-Qiang; Hou, Ling; Huang, Guan-Wang; Tian, Jun-Qiang; Wang, Guo-Jiang; Journal of Chemical Research; vol. 40; 9; (2016); p. 573 – 575;,
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