Related Products of 933190-51-3,Some common heterocyclic compound, 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, molecular formula is C6H3BrClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzyl alcohol (0.3 mL, 2.98 mmol) was dissolved in tetrahydrofuran (40 mL) under nitrogen and cooled to 0 C in an ice water bath. Sodium hydride (0.25 g) was added and the solution was stirred at 0 for 30 min. 8-bromo-6-chloroimidazo[1,2-b]pyridazine (462 mg, 1.99 mmol) in tetrahydrofuran (50 mL) was added dropwise and the mixture was slowly returned to room temperature and stirred for 1 h.The reaction was quenched with saturated sodium chloride solution (50 mL), extracted with ethyl acetate (500 mL), washed with organic phase (50 mL) and saturated sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, concentrated under reduced pressure and the residue was subjected to column chromatography (V (ethyl acetate) / V (petroleum ether) = 1/2) to give 0.26 g of an oily product in a yield of 50%.
The synthetic route of 933190-51-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CHENG, CHANGCHUNG; ZHANG, YINGJUN; LIU, BING; LONG, BOHUA; CHEN, YU; CHENG, ZHIXIN; (202 pag.)TW2017/6256; (2017); A;,
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