Reference of 883499-24-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 883499-24-9, name is 1-Bromo-2-chloro-3-fluorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of l-brmo-2-chloro-3-fluoro benzene (1.0 g, 4.79 mmol) in toluene (20mL) were added phenyl boronic acid(875 mg, 7.18 mmol), Na2C03 (1.52 g, 14.35 mmol),water (5 mL) and degassed for 10 min in argon atmosphere. Then to it was added Pd(PPh3)4 (553 mg, 0.48 mmol) and again degassed for 5 min. The reaction was heated to 100C for 16 h. The reaction mixture was then cooled to 25C, filtered through celite and washed with ethyl acetate. The separated organic layer was washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure to get the crude product which was purified by combiflash column chromatography using hexane to get 2-chloro-l-fluoro-3- phenylbenzene (920 mg, 93%) as yellow, sticky liquid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-chloro-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALANINE, Alexander; AMREIN, Kurt; BLEICHER, Konrad; FASCHING, Bernhard; HILPERT, Hans; KOLCZEWSKI, Sabine; KROLL, Carsten; SCHAEUBLIN, Adrian; ZAMPALONI, Claudia; (176 pag.)WO2018/189065; (2018); A1;,
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