Adding a certain compound to certain chemical reactions, such as: 19230-27-4, name is 1,3-Dibromo-2-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19230-27-4, Recommanded Product: 1,3-Dibromo-2-chlorobenzene
To a mixture of 1,3-dibromo-2-chlorobenzene (Combi-Blocks catQA-2717: 2.2 g, 8.14 mmol), Pd(OAc)2 (0.183 g, 0.814 mmol) and cesium carbonate (6.63 g, 20.34 mmol) in 1,4-dioxane (30 ml) was added 1,4-dioxa-8-azaspiro[4.5]decane (Aldrich cat178365: 1.165 g, 8.14 mmol) under N2. The reaction mixture was stirred at 90 C. overnight. After the reaction was cooled to room temperature it was quenched with saturated aqueous NaHCO3, and extracted with ethyl acetate (3¡Á50 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-20%) to afford the desired product. LC-MS calculated for C13H16BrClNO2 (M+H)+: m/z 332.0; found: 332.0/334.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-chlorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Incyte Corporation; Wu, Liangxing; Qian, Ding-Quan; Lu, Liang; Lajkiewicz, Neil; Konkol, Leah C.; Li, Zhenwu; Zhang, Fenglei; Li, Jingwei; Wang, Haisheng; Xu, Meizhong; Xiao, Kaijiong; Yao, Wenqing; (101 pag.)US2018/177784; (2018); A1;,
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