Synthetic Route of 56961-77-4,Some common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, and added at 120 will have the N 1 , the N 1 ,the N 3 – triphenyl benzene-1,3-diamine (20.0g), 1- bromo-2,3-dichlorobenzene ( 6.4g),Pd-132 (0.2g ), NaOtBu (6.8g) and xylene (70ml) was stirred for 2 hours the flask washeated. The reaction mixture was cooled until room temperature, water and ethyl acetateto carry out a liquid. Then, the use of silica gel column chromatography (eluent:toluene / heptane = 4/6 (volume ratio)) to be purified, to thereby obtain the N 1 , theN 1 ‘ – (2- chloro-1,3-phenylene yl) bis (the N 1 , the N 3 , the N 3 – phenyl-trityl-1,3-diamine) (15.0g)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,3-dichlorobenzene, its application will become more common.
Reference:
Patent; Kwansei Gakuin School Corporation; Tian, Shanzuoci; Zhong, Zhongzongyiliang; Zhong, Daoguiyi; Ping, Jingdagui; Xiao, Yeyangping; Zhi, Lianyizhi; Ni, Jingping; Song, Xiawusi; Sheng, Tianlizhao; (405 pag.)CN105431439; (2016); A;,
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