Adding a certain compound to certain chemical reactions, such as: 367-22-6, name is 4-Chloro-3-fluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 367-22-6, SDS of cas: 367-22-6
(145d) 4-Amino-Lambda/-(4-chloro-3-fluoro-phenyl)-2-methyl-5-nitro-benzamide 4-Amino-2-methyl-5-nitro-benzoylchloride (950 mg, 4.4 mmol) was added to a stirred mixture of 4-chloro-3-fluoro-aniline (644 mg, 4.4 mmol) and TEA (0.74 ml_, 5.3 mmol) in 80 ml. THF. After stirring for 2h the mixture was concentrated /.vac. The residue was taken up in water and filtrated.Yield: 1.4O g (98%) mass spectrum: (M+H)+ = 324/326 (chlorine isotopes)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PFAU, Roland; ARNDT, Kirsten; DOODS, Henri; HAUEL, Norbert; KLINDER, Klaus; KUELZER, Raimund; MACK, Juergen; PRIEPKE, Henning; STENKAMP, Dirk; WO2010/34796; (2010); A1;,
Chloride – Wikipedia,
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