Some common heterocyclic compound, 6781-98-2, name is 2-Chloro-1,3-dimethylbenzene, molecular formula is C8H9Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 6781-98-2
General procedure: To a 50 mL Schlenk tube containing base (1.5 mmol) and precatalyst 4a (1 mol %, 0.0083 g) purged with N2 (three times), amine (1.2 mmol) was added via syringe, and the resulted mixture was allowed to stir at room temperature for 2-3 min. Solvent (1 mL) was then injected via syringe followed by the aryl chloride (1.0 mmol). If the aryl chloride was a solid, it was introduced into the vial prior to purging with N2. At this time, the reaction was stirred for 24 h at 100 C. After cooling to the room temperature, the reaction mixture was concentrated in vacuo and directly purified via silica gel flash chromatography. N-(2,6-Dimethylphenyl)-2,4,6-trimethylaniline (26) ;1H NMR (CDCl3, 400 MHz, 298 K): delta=6.97 (d, J=7.6 Hz, 2H), 6.81-6.78 (m, 3H), 4.71 (br s, 1H), 2.25 (s, 3H), 1.99-1.95 (m, 12H); 13C NMR (CDCl3, 100 MHz, 298 K): delta=142.14, 138.94, 131.43, 130.40, 129.17, 128.74, 128.34, 120.91, 20.55, 19.06, 18.96; GC-MS: tR=16.270 min, m/z=239.1 [M]+, 239.1, 222.1, 208.1, 132.0, 120.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6781-98-2, its application will become more common.
Reference:
Article; Fang, Weiwei; Jiang, Jian; Xu, Yong; Zhou, Juefei; Tu, Tao; Tetrahedron; vol. 69; 2; (2013); p. 673 – 679;,
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