Synthetic Route of 96558-78-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 96558-78-0 as follows.
3-Bromo-5-chloroaniline (20 g, 96.87 mmol) was added dropwise to 103 N-chlorosuccinimide (12.93 g, 96.87 mmol) in 52 DMF (100 mL) at rt. The resulting solution was stirred at rt for 16 h. The solvent was removed in vacuo. The crude product obtained was purified by flash silica chromatography (5 to 10% 57 EtOAc in 148 petroleum ether) to afford 687 3-bromo-4,5-dichloroaniline (8 g, 34%) as a brown solid; 1H NMR (300 MHz, DMSO, 30 C.) 6.02 (2H, s), 6.83 (1H, d), 6.94 (1H, d); m/z: ES+ [M+H]+=242.
According to the analysis of related databases, 96558-78-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
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