Reference of 2106-04-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2106-04-9 name is 3-Chloro-2-fluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of (E)-N-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide 17 (6.0 g, 2.7 mmol) and acetic acid (45 mL) was added 3-fluoroaniline (18a, 3.3 g, 3.0 mmol) at room temperature. The reaction mixture was heated up to reflux temperature for 1 h. After completion of the reaction, the resulting mixture was cooled to room temperature. The solid separated was filtered and washed with ether to give 19a, 6.5 g (83%);
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-2-fluoroaniline, and friends who are interested can also refer to it.
Reference:
Article; Marvania, Bhavin; Lee, Pei-Chih; Chaniyara, Ravi; Dong, Huajin; Suman, Sharda; Kakadiya, Rajesh; Chou, Ting-Chao; Lee, Te-Chang; Shah, Anamik; Su, Tsann-Long; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 1987 – 1998;,
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