Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-50-5, name is 4-Chloro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Chloro-2-methoxyaniline
Step 1: In a sealed tube 4-chloro-2-anisidine (3.0 g, 19.0 mmol), 5-chloro-2-trifluromethylpyridine (3.8 g, 20.9 mmol) and Cs2C03 (8.02 g, 24.7 mmol) were mixed in toluene (50 mL). The resulting mixture was purged with nitrogen, added Pd(OAc)2 (0.64 g, 2.8 mmol) and X-phos (0.45 g, 0.95 mmol) and heated at 140 C for 12 h. After completion of the reaction, the reaction mixture was filtered through Celite bed and concentrated under vacuum. The residue obtained was diluted with ethyl acetate (200 mL), washed with water, brine solution and dried over anhydrous Na2S04. The organic phase was concentrated and purified by the column chromatography (230-400 size mesh) to get the desired product /V-(4-chloro-2-methoxyphenyl)-6- (trifluoromethyl)pyridin-3-amine (3.5 g, 61.4%). LC MS: 303.0 (M+H), RT- 3.45 min, 96.03% (max) Method A-0.1% HCOOH; B-ACN Flow = 1.5 mU in. Column-ZORBAX XDB C18 (50X 4.6mm-5pm) positive Mode 1H NMR (300 MHz, DMSO-d6) : delta 8.42 (s, 1H), 8.27 (d, J = 2.58 Hz, 1H), 7.58 (d, J = 8.7 Hz, 1H), 7.21-7.27 (m, 2H), 7.16 (d, J = 2.16 Hz, 1H), 6.97 (dd, J = 2.17, 9.80 Hz, 1 H), 3.81 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93-50-5.
Reference:
Patent; MERCK PATENT GMBH; SPANGENBERG, Thomas; (129 pag.)WO2016/827; (2016); A1;,
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