Synthetic Route of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Following the similar procedures as for compound 13a gave compound13b, white solid, 55percent. 1H NMR (400 MHz, CDCl3) delta 8.10 (d,J=5.1 Hz, 1H), 7.43 (d, J=1.8 Hz, 1H), 7.37 (d, J=8.2 Hz, 1H),7.21?7.15 (m, 1H), 6.84 (d, J=5.1 Hz, 1H), 4.79 (t, J=5.6 Hz, 1H),4.65?4.59 (m, 2H), 3.78?3.68 (m, 1H), 3.62?3.53 (m, 2H), 3.21 (t,J=6.3 Hz, 2H), 3.05?2.95 (m, 2H), 2.82 (s, 3H), 2.78 (s, 3H), 2.58 (t,J=6.9 Hz, 2H), 2.43?2.33 (m, 2H), 2.08?1.98 (m, 4H), 1.87?1.76 (m,4H), 1.72?1.61 (m, 2H). 13C NMR (126 MHz, CDCl3) delta 169.41, 154.57,146.52, 144.37, 140.39, 132.47, 130.98, 130.44, 129.56, 127.05,114.53, 112.28, 55.59, 54.97, 53.01, 46.27, 45.72, 44.85, 38.50, 29.69,28.71, 28.56, 26.62, 22.37. HRMS (ESI): calcd for C26H36Cl2N5O3S [M+H]+: 568.1910; found 568.1898. Retention time 2.35 min,>97percentpure.
The synthetic route of 102-49-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Qin, Li-Huai; Wang, Zhi-Long; Xie, Xin; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3559 – 3572;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics