Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H6ClF3N2
318 mg (3 MMOL) BRCN are dissolved in 0.6 ml acetonitrile and treated with 6 ML water. To this solution, 575 mg (2.73 MMOL) 5-CHLORO-6-TRIFLUOROMETHYL- benzene-1, 2-diamine, dissolved in 6 ML METHANOL, are added dropwise within 30 min. After 2 hrs of stirring at room temperature, the reaction mixture is concentrated and the water solution extracted 2X with ethyl acetate. The combined organic phases where RE-EXTRACTED 1x with water. The combined water phases where made alkaline (pH=8) with saturated NAHC03-SOLUTION and extracted 2x with ethyl acetate. The combined organic phases where dried, filtered and evaporated. Yield : 611 MG (95 %) 7, red solid
The synthetic route of 157590-59-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; WO2005/4864; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics