Adding a certain compound to certain chemical reactions, such as: 39989-43-0, name is 3,5-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39989-43-0, category: chlorides-buliding-blocks
A mixture of [(3,5-dichlorophenyl) methyl]amine (100 mg), 2-bromo- 1,1bis (methyloxy)ethane (123 muL) and K2C03 (95 mg) in anhydrous DMF (2 mL) was processed by microwave irradiation at 150C for 10 min (3 cycles). The mixture was allowed to cool to rt, water was added and mixture extracted three times with AcOEt, the organic phases collected, washed with brine, dried and evaporated under vacuum to give a crude which was purified by flash cromathography eluting with CH: AcOEt= 9: 1 to 85:15 to afford the title compound (120 mg) as a colourless oil. MS (ES/+) : m/z=264 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichlorobenzylamine, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/121122; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics