Application of 56961-77-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56961-77-4 name is 1-Bromo-2,3-dichlorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 1-bromo-2,3-dichlorobenzene [r-1] (22.6 g, 100 mmol), sodium t-butoxide (29.6 g, 308 mmol), 2,2?-bis (diphenylphosphino)-1 , 1 ?-binaphthyl [I3INAP] (2.51 g, 4.0 mmol), bis(dibenzylideneacetone) palladium (0) [Pd2 (dba) 31(1.83 g, 2.0 mmol), and toluene (400 ml), aniline [r-2] (18.5 ml, 203 mmol) was added under a nitrogen atmosphere at room temperature, and the resulting mixture was heated and stirred at 1000 C. for 26 hours. The reaction solution was cooled to room temperature, and was filtered using silica gel column chromatography, and a solvent was distilled oil under reduced pressure to obtain a crude product. Thereafier, the resulting crude product was washed with toluene to obtain 2-chloro-N,N?-diphenyl- 1 ,3-benzenediamine [r-3] (18.4 g, yield 63%) as a white solid. The structure of the compound thus obtained was identified with an NMR spectrum. 1H-NMR (400 MHz, CDC13): &6.08 (s, 2H), 6.80 (s, 2H), 6.99 (t, 1H), 7.04 (U, J=1.1, 7.3 Hz, 2H, (CH)2CH (CR2)2), 7.18 (dd, 4H), 7.32 (dd, 4H). 13C-NMR (101 MHz, CDC13): 107.1 (2C), 109.4,120.4 (4C), 122.5 (2C), 127.0, 129.3 (4C), 141.1 (2C), 141.6 (2C).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,3-dichlorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; Hatakeyama, Takuji; NAKATSUKA, Soichiro; GOTOH, Hajime; SASADA, Yasuyuki; YANAI, Motoki; IKUTA, Toshiaki; (337 pag.)US2018/69182; (2018); A1;,
Chloride – Wikipedia,
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