Synthetic Route of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of the dibromofluoroalcohol (1.0 equiv.), acid chloride (1.1-1.5 equiv.) and triethylamine (2.2-3.0 equiv.) in THF was stirred for 1 h at 0 C, then for additional appropriate period (usually 2-3 h) at room temperature. As in the cases of 1e, 1f, 8c-e catalytic amount of 4-dimethylaminopyridine was also added. Usual workup (addition of water, extraction with diethyl ether or ethyl acetate, dried over MgSO4) followed by purification by silica gel column chromatography (mixture of hexane and EtOAc as eluent) gave the corresponding ester.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-Phenyl carbonochloridothioate, its application will become more common.
Reference:
Article; Saito, Akio; Tojo, Manabu; Yanai, Hikaru; Wada, Fukiko; Nakagawa, Muga; Okada, Midori; Sato, Azusa; Okatani, Rieko; Taguchi, Takeo; Journal of Fluorine Chemistry; vol. 133; (2012); p. 38 – 51;,
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