Electric Literature of 367-22-6,Some common heterocyclic compound, 367-22-6, name is 4-Chloro-3-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To the solution of acid in 55 DMF (7ml), were added 56 EDC.HCl (1mmol) and 57 HOBt (1mmol) respectively at 0C. The solution was stirred for 30min followed by addition of 58 (S)-1-phenylethan-1-amine (0.8mmol) and 59 NEt3 (1.33mmol). The reaction mixture was stirred for 1h at 0C and then for 12hat room temperature. The reaction mixture was quenched by saturated NaHCO3 and then extracted with EtOAc. The organic layer was dried with Na2SO4 and concentrated under reduced pressure. The crude residue was purified by column chromatography to obtain pure 60 15a.
The synthetic route of 367-22-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Karale, Uttam B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Choudhari, Amit S.; Shukla, Manjulika; Gaikwad, Vikas R.; Mahizhaveni; Chopra, Sidharth; Misra, Sunil; Sarkar, Dhiman; Sriram, Dharmarajan; Dusthackeer, V.N. Azger; Rode, Haridas B.; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 315 – 328;,
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