Application of 2106-04-9, These common heterocyclic compound, 2106-04-9, name is 3-Chloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium nitrite (9.7 g, 0.14 mol) was dissolved in 25 mL of water and added to the solution cooled to -5 C.3-chloro-2-fluoroaniline (20.0 g, 0.14 mmol) in trifluoroacetic acid (100 mL),Sodium azide (9.1 g, 0.14 mol) dissolved in 5 mL of water was added dropwise to the reaction solution, and the mixture was dropped.The reaction mixture was stirred at 0 C for 2 hr then quThe organic phase is dried and filtered.After concentration, the title compound (18.7 g) was obtained.Used directly in the next step.
The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Wu Yongyong; Song Zhiquan; Cai Jiaqiang; Zhu Jiawang; Wang Lichun; Wang Jingyi; (71 pag.)CN109867660; (2019); A;,
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