These common heterocyclic compound, 108-41-8, name is 1-Chloro-3-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 108-41-8
General procedure: Under N2 atmosphere, KOtBu (1.0 mmol), NHC-Pd(II)-Im 2a (1.0 mol %), dry dioxane (1.0 mL), morpholine 3 (0.8 mmol), and aryl chloride 4 (0.7 mmol) were successively added into a Schlenk reaction tube. The mixture was stirred at 70 C for 3 h. The solvent was removed under reduced pressure and the residue was purified by a flash chromatograph on silica gel to give the pure products 5.
The synthetic route of 1-Chloro-3-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhu, Lei; Gao, Ting-Ting; Shao, Li-Xiong; Tetrahedron; vol. 67; 29; (2011); p. 5150 – 5155;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics