Related Products of 2732-80-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2732-80-1, name is 2-Bromo-1-chloro-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
The 2-bromo-1-chloro-4-methoxybenzene (25.0 g, 113 mmol) [Oakwood cat035670] was dissolved in carbon disulfide (250 mL), and the acetyl chloride (12 mL, 170 mmol) and aluminum trichloride (37.6 g, 282 mmol) were added. The reaction was heated to reflux and monitored by LC/MS. After heating for 1 h, the reaction became two layers. The reaction allowed to cool to room temperature and poured over ice. The slurry was extracted with ethyl acetate 3¡Á, the combined organic layer was washed with brine, dried over magnesium sulfate and concentrated to give 1-(4-bromo-5-chloro-2-hydroxyphenyl)ethanone as a solid (28.0 g, 99%). 1H NMR (300 MHz, CDCl3) delta 12.12 (s, 1H), 7.78 (s, 1H), 7.31 (s, 1H), 2.62 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1-chloro-4-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Combs, Andrew P.; Sparks, Richard B.; Maduskuie, Jr., Thomas P.; US2013/261101; (2013); A1;,
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