These common heterocyclic compound, 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 41965-95-1
Example 3 : 10- [(3-chloro-4-methoxybenzyl)amino] -2-ethyl- 1 ,2,3,4- tetrahydrobenzo [b] [ 1 ,6] naphthyridine-8-carbonitrile [00151] A mixture of 5 (0.18 mmol), 3-chloro-4-methoxybenzylamine hydrochloride (0.18 mmol), Nal (0.009 mmol), and phenol (0.18 mmol) was heated at 130 C for 2.5 h (Scheme 4). The reaction mixture was diluted with Et20 (30 mL) and washed with IN NaOH (3xlmL). The organic layer was dried over Na2S04, filtered and evaporated under reduced pressure. The residue was purified by Flash Chromatography (5% MeOH in AcOEt) to give the desired compound C (38% of yield). MS ESI (m/z) 407 (M+H)+, 1H NMR (300 MHz, CDC13) delta 8.32 (d, 1H, J= 1.2 Hz), 7.97 (d, 1H, J= 8.7 Hz), 7.71 (dd, lH, Ji= 1.8, J2= 8.7 Hz), 7.37 (d, 1H, J= 2.1 Hz), 7.17 (dd, lH, Ji= 2.1, J2= 8.4 Hz), 6.94 (d, 1H, J= 8.4 Hz), 4.56 (d, 2H, J= 5.7 Hz), 4.12 (br s, 1H), 3.92 (s, 3H), 3.59 (s, 2H), 3.22 (t, 2H, J= 6.0 Hz), 2.87 (t, 2H, J= 6.0 Hz), 2.66 (q, 2H, J= 7.2 Hz), 1.18 (t, 3H, J= 7.2 Hz).
The synthetic route of 3-Chloro-4-methoxybenzylamine Hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; FIORITO, Jole; ARANCIO, Ottavio; WASMUTH, Andrew; WO2015/9930; (2015); A2;,
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